Wednesday 29 August 2012

Benifits of Deflazacort


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Deflazacort treatment started between 4 and 8 years of age. Treatment started between 6 and 8 years of age. The results were compared with age-matched controls in the two groups (19 for protocol-N and 30 for protocol-T). For the boys treated with protocol-N, 97% were ambulatory at 9 years (control, 22%), 35% at 12 years (control, 0%), 25% at 15 years (control, 0%). For the 32 boys treated with protocol-T, 100% were ambulatory at 9 years (control, 48%), 83% at 12 years (control, 0%) and 77% at 15 years (control, 0%). No aids or leg braces were used for ambulation. In boys 13 years and older, a scoliosis of >20° developed in 30% of the boys on protocol-N, 16% on protocol-T and 90% of controls. For protocol-N, no cataracts were observed while in protocol-T, 30% of boys had asymptomatic cataracts that required no treatment. Fractures occurred in 19% (control 16%) of boys on protocol-N and 16% (control, 20%) of boys on protocol-T. This report illustrates: (a) the importance of collaborative studies in developing treatment protocols in Duchene muscular dystrophy and (b) the long-term beneficial effects of deflazacort treatment in both protocols. The protocol-T seems to be more effective and frequently is associated with asymptomatic cataracts.

Deflazacort is a corticosteroid. Deflazacort works by preventing or reducing inflammation. It is used to treat a number of conditions that are characterized by excessive inflammation. Deflazacort suppresses the immune system and so can be used to treat autoimmune diseases. Deflazacort can help to prevent and to treat the rejection of transplanted organs. It can also be used in the treatment of certain types of cancers.


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